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Spec 및 활용분야

원리 및 특징	GC-TOF/MS는 저분자 대사체 프로파일링등에 활용되는 장비로써 2D의 기능은 복잡한 시료 내 분리가 어려운 다양한 성분을 한번의 분석으로 구현할 수 있다. 이차원 크로마토그래프와 초고속 스펙트럼 수집을 통해 분리 및 검출이 어려운 성분들을 deconvolution해 낼 수 있는 비행시간형 질량분석기로 구성되어 있어서 대단위 시료를 장비 오염 없이 사용할 수 있으며 다목적 자동화 시료처리 장치를 통해 광범위한 유기물 분석이 가능하다.
구성 및 성능	○ 이차원 기체크로마토그래프 - 다기능 포함 자동 주입 시스템 - Thermal modulator for high-definition sample resolving capabilities ○ 비행시간형 질량분석기 - High spectral acquisition rate (> 50 spectra/sec) - Mass range : 5~1000 m/z - Mass resolution : Unit mass resolution - Dynamic range : 5 order of magnitude - Peaks ranging from 50 to 200 milliseconds wide are capable of collecting data at rates of 100 Hz in order to adequately characterize the shape of the chromatographic peak - Automated peak finding, true signal deconvolution without interfering signal - Sensitivity : S/N ratio 10:1 at HCB 2pg/uL detection (1ul / Splitless) - Automated peak finding, true signal deconvolution without interfering signal 0
활용분야	○ 효모 스테롤 profiling 분석 ○ 원유의 생물지표 분석 ○ kava 추출물 등 천연물로 부터 물질구조 분석 ○ anabolic sterols 약물 분석 ○ Fluorotelomer alcohols/ PAH, PCB, OCP, PBDE, and polycyclic musk 정성, 정량 ○ 식품관련 올리브오일의 특성, 음료 속 황 함유 물질, 농약 분석

Cyanidin is an agonistic ligand for peroxisome proliferator-activated receptor-alpha reducing hepatic lipid

Yaoyao Jia, Jin-Young Kim, Hee-jin Jun, Sun-Joong Kim, Ji-Hae Lee, Minh Hien Hoang, Hyun Sook Kim, H

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2013

피부사상균에 대한 편백정유의 Mono-및 Sesquiterpene 항진균 활성 비교

곽기섭 ( Ki Seob Gwak ) , 박미진 ( Mi Jin Park ) , 정의배 ( Eui Bae Jeung ) , 장제원 ( Je Won Chang

한국목재공학회, 2006

삼나무 흑심재 추출물의 피부사상균에 대한 항진균 활성

이수연 ( Su Yeon Lee ) , 곽기섭 ( Ki Seob Gwak ) , 이전제 ( Jun Jae Lee ) , 여환명 ( Hwan Myeong Yeo

한국목재공학회, 2009

편백정유의 항산화활성

박미진 ( Mi Jin Park ) , 최원실 ( Won Sil Choi ) , 민병철 ( Byeong Cheol Min ) , 김호용 ( Ho Yong Ki

한국목재공학회, 2008

Catalytic activity of CeIVO2Ce2IIIO3-silica mesoporous composite materials for oxidation and esterification reactions

Nabanita Pal, 조은범, Dukjoon Kim, Chamila Gunathilake, Mietek Jaroniec

Chemical Engineering Journal, 2015

Purification of Novel Acetylcholinesterase Inhibitor from Edible Plants

이규승

고려대학교, 2015

Characterization of Novel Acetylcholinesterase Inhibitor from Edible Plants

이상일

고려대학교, 2015

(π-Allyl)Pd Complexes Containing N-Heterocyclic Carbene and Pseudohalogen Ligands – Synthesis, Reactivity toward Organic Isothiocyanates and Isocyanides, and Their Catalytic Activity in Suzuki–Miyaura Cross-Couplings

Kim, H.-K. Lee, J.-H. *Kim,Y.-J. Zheng, Z. N. Lee, S. W

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2013

Inhibitory Effect of Natural Edible Plant Extract against Acetylcholinesterase

Na Young Lee

고려대학교, 2013

Effects of pyrolysis temperature on soybean stover- and peanut shell-derived biochar properties and TCE adsorption in water

Mahtab Ahmad, Sang Soo Lee, Xiaomin Dou b, Dinesh Mohan, Jwa-Kyung Sung, Jae E Yang, Yong Sik Ok

BIORESOURCE TECHNOLOGY, 2011

Neuroprotective Effect of Edible Plant Extracts against Amyloid Beta Peptide-induced Toxicity

Bo Ram Jang

고려대학교, 2012

Degradation properties of ibuprofen using photocatalytic process

채금화, 나승민, 안윤경, 이세반, 김지형

한국환경과학회지, 2012

Significant DEP degradation by combined advanced oxidation process in aqueous solution

나승민, 안윤경, Mingcan Cui, 김지형

JOURNAL OF ENVIRONMENTAL MANAGEMENT, 2012

Antidiabetic stilbene and anthroquinone derivatives from Rheum undulatum

Choi, S.Z., Lee, S.O., Jang, K.U., Chung, S.H., Kang, H.C., Yang, E.Y., Cho, H.J., Lee, K.R.

Archives of Pharmacal Research, 2005

수동 및 자동화 액체 크로마토그래피 칼럼에 대한 PCDDs/Fs 및 다이옥신과 유사한 PCBs의 용출패턴 비교

안윤경, 신정화, 유선영, 김지형, 홍종기

분석과학학회지, 2005

매실 과육 성분분석 및 매실종별 성분비교

이학주, 이오규, 신현철, 조현진,

한국목재공학회, 2006

Five new labdane diterpene from Aster ohrai

Choi, S. Z., Kwon, H. K., Choi, S. U., Kang, R. L.

Journal of Natural products, 2002

Phytochemical constituents of Circium setidens Nakai and their cytotoxicity against human cancer cell lines

Lee, W. B., Kwon, H. Ch., Cho, O. R., Lee, K. Ch., Choi, S. U., Baek, N. I., Lee, K. R.

Archives of Pharmacal Research, 2002

PAHs로 오염된 침전물의 초음파 처리시 입자크기가 미치는 영향

나승민, 김지형, 최명찬, 안윤경, Linda K Weavers

한국환경과학회지, 2010

Inhibitory Effect of Zeatin, Isolated from Fiatoua villosa, on Acetylcholinesterase Activity from PC12 Cells

Ho-Jin Heo, Seong-Chan Hong, Hong-Yon Cho, Bumshik Hong, Hye-Kyung Kim, Eun-Ki Kim, Dong-Hoon Shin

Molecules and Cells, 2002

Pd-nanoparticle-catalyzed conversion of Fe nanoparticles into diameter- and length-controlled Fe2P nanorods

이광렬

Angew. Chem. Int. Ed., 2010

매실 과육성분의 분석

이오규,이학주,신유수,안윤경,조현진,신현철,강하영

한국약용작물학회지, 2007

Anti-adipocyte Differentiation Activity and Chemical Composition of Essential Oil from Artemisia annua

Dae Il Hwang, Kyung-Jong Won, Do-Yoon Kim, Seok Won Yoon, Joo-Hoon Park, Bokyung Kim and Hwan Myung Lee

Natural Product Communications, 2016

Anti-adipocyte Differentiation Activity and Chemical Composition of Essential Oil from Artemisia annua

Dae Il Hwang, Kyung-Jong Won, Do-Yoon Kim, Seok Won Yoon, Joo-Hoon Park, Bokyung Kim and Hwan Myung Lee

Natural Product Communications, 2016

Potential Skin Regeneration Activity and Chemical Composition of Absolute from Pueraria thunbergiana Flower

Do-Yoon Kim, Kyung-Jong Won, Dae-Il Hwang, Seok Won Yoon, Su Jin Lee, Joo-Hoon Park, Myeong Sik Yoon, Bokyung Kim and Hwan Myung Lee

Natural Product Communications, 2015

Chrysanthemum boreale Makino essential oil induces keratinocyte proliferation and skin regeneration

Do Yoon Kim, Kyung-Jong Won, Mi-So Yoon, Dae Il Hwang, Seok Won Yoon, Joo-Hoon Park, Bokyung Kim Hwan Myung Lee

NATURAL PRODUCT RESEARCH, 2014

산국 에센셜오일의 SNARE protein 발현 억제와 아토피피부염 개선 효능 연구

황대일(지도교수 이환명)

호서대학교 , 2017

Cinnamyl Alcohol, the Bioactive Component of Chestnut Flower Absolute, Inhibits Adipocyte Differentiation in 3T3-L1 Cells by Downregulating Adipogenic Transcription Factors

Dae Il Hwang, Kyung-Jong Won, Do-Yoon Kim, Bokyung Kim and Hwan Myung Lee

AMERICAN JOURNAL OF CHINESE MEDICINE, 2016

Skin Regeneration Effect and Chemical Composition of Essential Oil from Artemisia montana

Mi-So Yoon, Kyung-Jong Won, Do Yoon Kim, Dae il Hwang, Seok Won Yoon, Bokyung Kim and Hwan Myung Lee

Natural Product Communications, 2014

Effect of Absolute From Hibiscus syriacus L. Flower on Wound Healing in Keratinocytes

Seok Won Yoon, Kang Pa Lee, Do-Yoon Kim, Dae Il Hwang, Kyung-Jong Won, Dae Won Lee, Hwan Myung Lee

Pharmacognosy Magazine, 2016

Effect of absolute from Hibiscus syriacus L. flower on wound healing in keratinocytes

Seok Won Yoon, Kang Pa Lee, Do-Yoon Kim, Dae Il Hwang, Kyung-Jong Won, Dae Won Lee, Hwan Myung Lee

Pharmacognosy Magazine, 2017

Cinnamyl Alcohol, the Bioactive Component of Chestnut Flower Absolute, Inhibits Adipocyte Differentiation in 3T3-L1 Cells by Downregulating Adipogenic Transcription Factors

Dae Il Hwang, Kyung Jong Won, Do Yoon Kim, Bokyung Kim, Hwan Myung Lee

AMERICAN JOURNAL OF CHINESE MEDICINE, 2017

Cinnamomum loureirii Extract Inhibits Acetylcholinesterase Activity and Ameliorates Trimethyltin-Induced Cognitive Dysfunction in Mice

Cho Rong Kim, Soo Jung Choi, Yoon Kyung Kwon, Jae Kyeom Kim, Youn-Jung Kim, Gwi Gun Park, Dong-Hoon Shin

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2016

Identification of Acetylcholinesterase Inhibitor from Edible Plants

Kim Hoi Seok

고려대학교, 2016

Antioxidant and Cognitive-Enhancing Activities of Arctium lappa L. Roots in Amyloid β Peptide1-42-Induced Mouse Model

Kwon Yoon Kyung

고려대학교, 2016

Flos Magnoliae and its Constituent Linoleic Acid Suppress T Lymphocyte Activation via Store-Operated Calcium Entry

Hyun JongKim, JoohanWoo, Yu RanNam, Joo HyunNam, Woo KyungKim,

AMERICAN JOURNAL OF CHINESE MEDICINE, 2019

GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia

Seung HunHan, SovannarithKorm, Ye GiHan, Soo YoungChoi, Soo HyunKim, Hee JinChung, KibeomPark, Jae YoungKim, KyungjaeMyung, Joo YongLee, HongtaeKim, Dong WookKim,

Autophagy, 2019

Stimulatory Effects of Paederia foetida Flower Absolute on the Skin Wound and Barrier Repair Activities of Keratinocytes

Ha BinKim, Kyung JongWon, Do YoonKim, Hye MinKang, Hwan MyungLee,

CHEMISTRY & BIODIVERSITY, 2020

Migration- and Proliferation-Promoting Activities in Human Keratinocytes of Zea mays Flower Absolute and Its Chemical Composition

Do YoonKim, Kyung JongWon, Dae IlHwang, Ha BinKim, YaliLi, Hwan MyungLee,

CHEMISTRY & BIODIVERSITY, 2020

Gardenia jasminoides extract and its constituent, genipin, inhibit activation of CD3CD28 co-stimulated CD4 ^{T cells via ORAI1 channel}

Hyun JongKim, Yu RanNam, Joo HanWoo, Woo KyungKim, Joo HyunNam,

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2020

Potential Beneficial Effects of Digitaria ciliaris Flower Absolute on the Wound Healing-Linked Activities of Fibroblasts and Keratinocytes

Soo MinPark, Kyung JongWon, Dae IlHwang, Do YoonKim, Ha BinKim, YaliLi, Hwan MyungLee,

PLANTA MEDICA, 2020

Microplastics from shoe sole fragments cause oxidative stress in a plant (Vigna radiata) and impair soil environment

Tae-Yang Lee, Lia Kim, Dokyung Kim, Sanghee An, Youn-Joo An

JOURNAL OF HAZARDOUS MATERIALS, 2022

Toxicity assessment of tire particles released from personal mobilities (bicycles, cars, and electric scooters) on soil organisms

Lia Kim, Tae-Yang Lee, Haemi Kim, Youn-Joo An

JOURNAL OF HAZARDOUS MATERIALS, 2022

Chemical toxicity screening of tire particle leachates from vehicles and their effects on organisms across three trophic levels

Lia Kim , Haemi Kim , Tae-Yang Lee , Youn-Joo An

Marine Pollution Bulletin, 2023

Atmospheric saccharide composition and its possible linkage with marine phytoplankton from North Pacific to the Antarctic regions

Ki Ae Kim, Na Rae Choi, Ha Young Yoo, Eunho Jang, Young Jun Yoon, Jiyeon Park, Chang Hoon Jung, Yong Pyo Kim, Ki-Tae Park, Ji Yi Lee

ATMOSPHERIC ENVIRONMENT, 2023